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Some cells in our bodies can enter a non-proliferative G0 state in response to environmental conditi… Show more Some cells in our bodies can enter a non-proliferative G0 state in response to environmental conditions (e.g. lack of nutrients) in which the cyclin and CDK proteins are no longer present in the cell. Once conditions improve, these cells can re-enter into G1. However other cells in our bodies, for example nerve cells, are terminally differentiated. This means that they have entered an irreversible G0 state. In contrast, cells can also be stuck at a G1 checkpoint in which cyclin-CDK complexes are present in cells, but are bound by inhibitor proteins. A G1 checkpoint arrest can occur, for example, in response to DNA damage or nutrient conditions. 1- Why is it beneficial for cells in multicellular organisms to have a distinct G0 phase rather than relying on a G1 checkpoint arrest? 2- What is a negative consequence of having cells in a multicellular organism enter an irreversible G0 state? • Show less60

Some cells in our bodies can enter a non-proliferative G0 state in response to environmental conditi… Show more Some cells in our bodies can enter a non-proliferative G0 state in response to environmental conditions (e.g. lack of nutrients) in which the cyclin and CDK proteins are no longer present in the cell. Once conditions improve, these cells can re-enter into G1. However other cells in our bodies, for example nerve cells, are terminally differentiated. This means that they have entered an irreversible G0 state. In contrast, cells can also be stuck at a G1 checkpoint in which cyclin-CDK complexes are present in cells, but are bound by inhibitor proteins. A G1 checkpoint arrest can occur, for example, in response to DNA damage or nutrient conditions. 1- Why is it beneficial for cells in multicellular organisms to have a distinct G0 phase rather than relying on a G1 checkpoint arrest? 2- What is a negative consequence of having cells in a multicellular organism enter an irreversible G0 state? • Show less

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